Phosphorylated Tau Levels in Donated Blood for Alzheimer’s Disease
Phosphorylated Tau Levels in Donated Blood
Recruiting
Observational Study
Alzheimer&Amp;#39;s Disease
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Sex
Any
Study type
Observational
Participants needed
250 (estimated)
Sponsor
The University of Texas Health Science Center, Houston · Other
Who this trial is looking for
This trial is looking for people who have donated blood samples. The goal is to study the levels of a specific protein related to Alzheimer’s disease in the blood to see if it can help understand risks for patients receiving blood transfusions.
Are You a Good Fit for This Trial?
You may be able to join if
I have donated plasma.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Alzheimer's disease (AD) is characterized by the accumulation of tau pathology, and blood-based biomarkers such as phosphorylated tau-217 (pTau217) have been identified as sensitive and specific predictors of AD risk. Recent studies suggest that individuals with elevated pTau217 levels may be at increased risk for developing AD and cognitive dysfunction. This observational study will examine donat…
Alzheimer's disease (AD) is characterized by the accumulation of tau pathology, and blood-based biomarkers such as phosphorylated tau-217 (pTau217) have been identified as sensitive and specific predictors of AD risk. Recent studies suggest that individuals with elevated pTau217 levels may be at increased risk for developing AD and cognitive dysfunction. This observational study will examine donated human plasma samples to determine whether some units of donated blood contain abnormally elevated pTau217 concentrations. The overarching goal is to evaluate whether transfusion of blood with higher pTau217 may pose risks to recipients and whether such units should be avoided in clinical use.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* The plasma sample from donators.
Exclusion Criteria:
* None.
Inclusion Criteria:
* The plasma sample from donators.
Exclusion Criteria:
* None.
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