BILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention

Recruiting N/A Interventional Study
Colorectal Cancer Prevention Colorectal Adenoma
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 – 80
Sex
Any
Study type
Interventional
Purpose
Prevention
Participants needed
40 (estimated)
Sponsor
Massachusetts General Hospital · Other
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About This Trial

This research study is a prospective, single-arm clinical trial to assess the effect of a dietary intervention for more plant-based and less animal-based food intake on secondary bile acid production, gut microbiota, circulating biomarkers and gene expression associated with colonic bile acid receptor activation and colorectal cancer.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Underwent screening or surveillance colonoscopy with removal of at least one adenoma. * Age 18-80 years. * Habitually consume a Western pattern diet. * BMI of at least 18.5 kg/m2 but less than 35 kg/m2 * Weight stable in last 3 months (loss or gain \<4%). * Subjects must be ab…
Contacts

Andrew T. Chan, MD, MPH

617-726-3212

achan@mgh.harvard.edu

CONTACT

Kai Wang, PhD

617-817-9246

kwang41@mgh.harvard.edu

CONTACT