Anesthesia sTrategy foR Organ Procurement In braiN dEath

Recruiting Phase 3 Interventional Study
Brain-dead Organ Donors
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Pivotal Trial This treatment is in the last trial phase before FDA approval. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
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At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 3
Study type
Interventional
Purpose
Treatment
Participants needed
270 (estimated)
Sponsor
University Hospital, Grenoble · Other
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About This Trial
The optimal anesthetic strategy during organ procurement in brain-dead donors remains unknown. The administration of anesthetic drugs in this setting aims to preserve hemodynamic stability in the face of reflex responses mediated by preserved spinal activity. Volatile anesthetics may blunt these reflexes, but their potential benefits in this context have never been investigated. This randomized t…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Eligible adult brain-dead donor hospitalized in intensive care unit in one of the participating center: * Confirmed diagnosis of brain death according to French public health code. * Ongoing organ donation procedure managed by the local organ procurement coordination team…
Contacts

Benoit CHAMPIGNEULLE, MD, PhD

+33476766879

BChampigneulle@chu-grenoble.fr

CONTACT

Anaïs ADOLLE

+33476766879

aadolle@chu-grenoble.fr

CONTACT