Phase II Clinical Study of SHR2554 Tablets Combined With Other Anti-tumor Treatments in Non-small Cell Lung Cancer Subjects

Inclusion Criteria: 1. Age range of 18-75 years old (including both ends), gender not limited; 2. Patients with locally advanced unresectable or metastatic non-small cell lung cancer diagnosed by pathology 3. ECOG score is 0 or 1 4. Expected survival period ≥ 12 weeks 5. Has a good level of organ function 6. Patients voluntarily joined the study and signed informed consent Exclusion Criteria: 1. Having difficulty swallowing or malabsorption syndrome or any other uncontrolled gastrointestinal disease (such as nausea, diarrhea, or vomiting), having undergone gastrectomy or gastric banding surgery, etc 2. Symptomatic or active central nervous system tumor metastasis 3. Previously or simultaneously suffering from other malignant tumors 4. Spinal cord compression that cannot be cured by surgery and/or radiotherapy 5. Accompanied by uncontrolled tumor related pain 6. Plan to receive any other anti-tumor treatment during this trial period 7. Receive other anti-tumor treatments within 4 weeks before the first medication 8. Having undergone major surgeries other than diagnosis or biopsy within 28 days prior to the first administration 9. Currently participating in other clinical studies or taking medication for the first time less than 4 weeks after the end of the previous clinical study 10. Moderate to severe pleural effusion with clinical symptoms 11. Individuals with active pulmonary tuberculosis infection within one year prior to the first use of medication 12. Subjects who have experienced severe infections within 30 days prior to their first medication use 13. Administer attenuated live vaccine within 30 days before the first use of medication. 14. History of immunodeficiency 15. Suffering from poorly controlled or severe cardiovascular and cerebrovascular diseases 16. History of interstitial pneumonia/non infectious pneumonia requiring hormone therapy in the past 17. AE caused by previous anti-tumor treatment has not recovered to CTCAE v5.0 level evaluation ≤ 1 18. Untreated active hepatitis 19. Female participants who are pregnant, breastfeeding, or planning to become pregnant during the study period. 20. There are other serious physical or mental illnesses or laboratory abnormalities present