Exploring Blood Cell Function and Oxidative Stress to Improve Diagnosis and Treatment in Pre-Capillary Pulmonary Hypertension
Recruiting
Observational Study
Pre-capillary Pulmonary Hypertension
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
120 (estimated)
Sponsor
University Hospital, Strasbourg, France · Other
Who this trial is looking for
This trial is looking for adults with pre-capillary pulmonary hypertension to help understand blood cell function and its impact on the disease. Participants will provide blood samples during routine check-ups over three years to see how these samples relate to their heart health and symptoms.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old.
I have been diagnosed with pre-capillary pulmonary hypertension.
I have a condition classified as Group 1, Group 3, or Group 4.
I have a scheduled follow-up appointment at the study center.
I can give informed consent to participate.
You may not be able to join if
I have postcapillary pulmonary hypertension.
I have a health condition that prevents safe blood sampling.
I am already in another clinical trial that interferes with this study.
I cannot provide informed consent.
I am pregnant or breastfeeding.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study aims to understand how blood cell (including peripheral blood mononuclear cells ((PBMCs) or platelets) function and oxidative stress can help physicians detect and predict the course of pre-capillary pulmonary hypertension. We hypothesize that changes in the mitochondrial function of blood cells and oxidative stress may be early markers of disease progression and severity.
The study wi…
This study aims to understand how blood cell (including peripheral blood mononuclear cells ((PBMCs) or platelets) function and oxidative stress can help physicians detect and predict the course of pre-capillary pulmonary hypertension. We hypothesize that changes in the mitochondrial function of blood cells and oxidative stress may be early markers of disease progression and severity.
The study will also explore how these blood markers relate to routine clinical and heart function measurements, such as echocardiography, right heart catheterization, 6-minute walk tests, and functional status, to see if they can help monitor patients over time and guide personalized care.
This is a non-interventional study. Blood samples will be collected during routine visits planned for diagnosis and follow-up. The study will include 120 patients diagnosed with pre-capillary pulmonary hypertension, who will be followed for 3 years. Blood samples will be taken up to three times per year to measure mainly oxidative stress and mitochondrial function in blood cells. These measurements will be compared with clinical tests to see if they can help predict the course of the disease.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adult patients (≥18 years) diagnosed with pre-capillary pulmonary hypertension confirmed by right heart catheterization
* Patients classified according to the international clinical classification:
* Group 1: Pulmonary arterial hypertension (PAH)
* Group 3: Pulmonary hype…
Inclusion Criteria:
* Adult patients (≥18 years) diagnosed with pre-capillary pulmonary hypertension confirmed by right heart catheterization
* Patients classified according to the international clinical classification:
* Group 1: Pulmonary arterial hypertension (PAH)
* Group 3: Pulmonary hypertension associated with chronic respiratory diseases and/or hypoxia
* Group 4: Chronic thromboembolic pulmonary hypertension (CTEPH)
* Patients scheduled for routine clinical follow-up and/or right heart catheterization at the study center.
* Ability and willingness to provide informed consent for participation and data analysis.
Exclusion Criteria:
* Postcapillary pulmonary hypertension (pulmonary arterial wedge pressure \>15 mmHg).
* Conditions precluding safe blood sampling (e.g., severe anemia, coagulopathy).
* Patients already enrolled in interventional clinical trials that could interfere with mitochondrial or oxidative stress measurements
* Patients unable or unwilling to provide informed consent
* Pregnancy or breastfeeding
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