No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 85
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
25 (estimated)
Sponsor
University of Virginia · Other
Who this trial is looking for
This trial is looking for adults with chest pain or shortness of breath to understand their fitness levels and whether a structured exercise program can help. Participants will do exercise tests and follow a remote high-intensity training program.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 18 and 85 years old.
I have been diagnosed with ANOCA.
I can use a wearable device for exercise monitoring.
I can participate in high-intensity training.
I can perform exercise testing.
I can provide answers to health-related questions.
I can understand and sign consent forms in English.
You may not be able to join if
I have systolic heart failure.
I have had a heart attack or heart surgery.
I cannot safely undergo exercise testing.
I am pregnant.
I cannot provide informed consent.
My life expectancy is less than 1 year.
I am currently imprisoned.
I have cognitive impairments.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it.
This study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) have poor cardiorespiratory fitness and its effect on quality of life.
Investigators also want to see if a structured high-intensity exercise program (HIIT), done wit…
The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it.
This study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) have poor cardiorespiratory fitness and its effect on quality of life.
Investigators also want to see if a structured high-intensity exercise program (HIIT), done with remote monitoring, can safely improve heart function, fitness, and quality of life in these patients. The Investigators will use a special exercise test called cardiopulmonary exercise testing to look for patterns that can help explain exercise limitations and quality of life in ANOCA before and after a remote high-intensity exercise program.
Trial Locations
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City
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Status
Eligibility Criteria
Inclusion Criteria:
* Age 18-85
* ANOCA (Anginal symptoms of chest pain or exertional dyspnea suspected to be from myocardial ischemia Invasive or CT coronary angiogram without obstructive epicardial CAD (≥50% left main or ≥70% other epicardial stenosis or fractional flow reserve ≤0.80)
* Able to u…
Inclusion Criteria:
* Age 18-85
* ANOCA (Anginal symptoms of chest pain or exertional dyspnea suspected to be from myocardial ischemia Invasive or CT coronary angiogram without obstructive epicardial CAD (≥50% left main or ≥70% other epicardial stenosis or fractional flow reserve ≤0.80)
* Able to use the wearable and participate in a remote exercise program
* Able to participate in intermittent high-intensity training.
* Able to perform cardiopulmonary exercise testing (CPET)
* Able to provide Health-related quality of life questionnaire (HRQOL)
* Participants must be able to understand and provide informed consent in English and complete the study questionnaire in English
Exclusion Criteria:
* Systolic heart failure (LVEF \<50% or NYHA class III symptoms)
* Prior myocardial infarction, coronary revascularization
* Inability to safely undergo cardiopulmonary exercise testing, based on investigator's judgment
* Pregnancy (due to unknown effects on CPET exercise markers)
* Inability to provide informed consent
* Life expectancy \<1 year
* Prisoners
* Cognitively impaired
* Non-English speaking
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