Evaluation of Antimicrobial Prophylaxis to Prevent Syphilis in Pregnancy in Patients at Risk in Rio de Janeiro, Brazil
Recruiting
Phase 2
Interventional Study
Congenital Syphilis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 45
- Sex
- Female
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 500 (estimated)
- Sponsor
- University of California, Los Angeles · Other
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About This Trial
The goal of this clinical trial is to learn if benzathine penicillin works to prevent maternal syphilis. It will also learn about the safety of benzathine penicillin. The main questions it aims to answer are:
* Does benzathine penicillin lower the rate of syphilis in pregnancy?
* What medical problems do participants have when taking benzathine penicillin? Researchers will compare benzathine peni…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Uncomplicated, viable pregnancy
2. Elevated risk for syphilis acquisition (one or more of the following):
1. Prior history of STIs last 3 years
2. HIV infection
3. Age \< 21 years
4. In a sexual partnership of \< 3 mo., or \> 3 sexual partners in the last 6 mo.
…
Contacts