Time Restricted Eating for Weight Loss Maintenance
Time Restricted Eating for WeIght LoSs MainTenance-2
Recruiting
N/AInterventional Study
Weight LossWeight GainWeight Loss Maintenance
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
25 – 65
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
110 (estimated)
Sponsor
NYU Langone Health · Other
Who this trial is looking for
This trial is looking for adults who have recently lost weight and want to prevent weight gain. Participants will follow a diet plan that restricts eating to certain hours and will track their food intake using a smartphone app.
Are You a Good Fit for This Trial?
Rules you outType 1 diabetesType 2 diabetesNarcolepsy
You may be able to join if
I have lost at least 5% of my weight in the last 3 months
My BMI is between 20.5 and 45
I am between 25 and 65 years old
I have a smartphone or will use one provided for me
You may not be able to join if
I am pregnant, trying to get pregnant, or breastfeeding
I have had or plan to have bariatric surgery
I have a history of an eating disorder
I am currently in another weight-management study
I take appetite suppressants
I skip meals or follow intermittent fasting
I work overnight shifts more than once a week
I cannot log my meals into the smartphone app for the required time
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The TWIST 2.0 Study is a 12-month, 2-arm RCT in adults with recent weight loss. We will examine the efficacy of TRE on weight (Aim 1a) and fat mass (Aim 1b) regain, and describe changes in subjective appetite following a mixed-meal tolerance test (Exploratory).
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* ≥5% non-surgical weight loss in the last 3 mos;
* current BMI 20.5-45 mg/kg2;
* between the ages 25 to 65 years old;
* own a smartphone or willing to use a smartphone if provided for self-monitoring. For in-person screening, eligible participants will provide signed informed c…
Inclusion Criteria:
* ≥5% non-surgical weight loss in the last 3 mos;
* current BMI 20.5-45 mg/kg2;
* between the ages 25 to 65 years old;
* own a smartphone or willing to use a smartphone if provided for self-monitoring. For in-person screening, eligible participants will provide signed informed consent and have their temporal eating patterns measured.
Exclusion Criteria:
* pregnant, trying to get pregnant or breastfeeding;
* previous or planned bariatric surgery;
* previous or current history of eating disorder;
* ongoing participation in another weight-management research study;
* continued participation in a weight loss program other than the proposed study;
* currently on appetite suppressants;
* currently following intermittent fasting; or skipping meals;
* eating window \<11h 59min/day;
* perform overnight shift work more than once a week;
* work that includes travel across one or more time zones;
* taking medications that affect body weight or would preclude TRE;
* unable or unwilling to provide informed consent;
* unable to participate meaningfully in the intervention (e.g., uncorrected sight and hearing impairment);
* unwilling to accept randomization assignment;
* unable to log at least 2 meals into the smartphone app for 70% (\~20 days) during of the run-in period;
* have type 1 or type 2 diabetes, or other conditions that would preclude restricted eating windows;
* narcolepsy,
* \>2.5 kg additional weight loss during run-in phase (weight regain is not an exclusion criteria);
* is non-English speaking (the mCC app is currently only available in English).
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