Combined Gastrointestinal Decontamination in Acute Severe Poisoning

Inclusion Criteria: Patient aged ≥18, intoxicated and hospitalised in intensive care AND * Main drug toxicant of functional type (any psychotropic or cardiotropic), adsorbable by activated charcoal And * Main toxicant identified by the history taken by a healthcare professional on the ward or during care prior to the ward And * Main toxicant identified within 3 hours of admission if the patient is already intubated on admission, or within 3 hours of intubation if the patient is intubated on the ward AND * Patient intubated for effects attributed to the toxic agent (neuro-respiratory or haemodynamic failure) AND * Patient with nasogastric tube or planned nasogastric tube and no contraindications AND * Main toxicant whose assay can be performed by the toxicology laboratory at Lariboisière Hospital AND Inclusion according to the emergency clause * Written informed consent from a parent/relative/trusted person. In the absence of a parent/relative/trusted person, the patient may be included under the emergency procedure and consent will be obtained as soon as possible. Exclusion Criteria: * No social security affiliation * Non-intubated patient * Contraindication to the administration of one of the study products (e.g. suspected digestive perforation, intestinal obstruction, inflammatory bowel disease, etc.) * Inability to insert a nasogastric tube * Repeated vomiting prior to inclusion, making digestive decontamination impossible * Digestive haemorrhage in progress or during the previous month * Ingestion of metals (e.g. iron, caesium, thallium, lead, copper, cadmium) * Isolated or predominant alcohol poisoning (e.g. ethyl alcohol, ethylene glycol, methanol) * Intoxication by gas (e.g. carbon monoxide or fire fumes) * Intoxication by a caustic product (acids or bases) * Main toxicant ingested under liquid form * Intoxication by a toxic lesion * Intoxication by a non-medicated product (e.g. party drugs) * Intubation for causes not attributed to the ingested toxic substance (e.g. massive inhalation pneumonia) * In-body carrier of drug pellets * Pregnant or breast-feeding patients * Patients being treated for dementia * Patient under guardianship or curatorship * Patients under legal protection * Patients deprived of their liberty