Fructose Intestinal Gluconeogenesis
Recruiting
N/A
Interventional Study
Healthy Participants
Obese But Otherwise Healthy Participants
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 20 – 55
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 40 (estimated)
- Sponsor
- Touro University, California · Other
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About This Trial
This study will test the hypothesis that within a defined range of fructose intake, the ability to convert fructose to glucose (via gluconeogenesis) in the small intestine plays a protective role for the liver, shielding it from the deleterious effects of fructose. We will investigate whether this protective effect of the intestine is impaired in individuals with obesity.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* BMI 30 to 38 kg/m2 (obese group) or BMI 19 to 25 kg/m2 (lean group)
Exclusion Criteria:
* Pregnancy or lactation within the past six months;
* Type 1 or 2 diabetes mellitus (including fasting glucose ≥126 mg/dL, HgbA1c ≥6.5%);
* History of liver disease or AST and ALT 2x abo…
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