Pre-emptive Scalp Infiltration With Low-dose Flurbiprofen and Ropivacaine for Postoperative Analgesia After Craniotomy
Recruiting
N/A
Interventional Study
Post-craniotomy
Pain
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 64
- Sex
- Any
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 216 (estimated)
- Sponsor
- Beijing Tiantan Hospital · Other
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About This Trial
Post-craniotomy pain is common and often associated with poor outcomes. Flurbiprofen axetil (FA) is an injectable NSAID for postoperative analgesia, however, the impact of local FA, remains elusive on post-craniotomy pain. As FA is highly lipophilic by merging into emulsified lipid microspheres, it has a high affinity to the surgical incision and inflammatory tissues to achieve targeted drug thera…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Age 18-64 years;
2. ASA physical status of I - II;
3. Scheduled for craniotomy under general anesthesia;
4. Anticipated tracheal extubation, recovery of consciousness and orientation within 2 hours after craniotomy.
Exclusion Criteria:
1. Glasgow Coma Scale \<15;
2. Unable …
Contacts