High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy /Segmentectomy
Recruiting
Phase 2
Phase 3
Interventional Study
Analgetic
Lung Cancer (NSCLC)
Video Assisted Thoracic Surgery (VATS)
Glucocorticoid
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 2/3
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 80 (estimated)
- Sponsor
- Rigshospitalet, Denmark · Other
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About This Trial
The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in patients undergoing VATS lobectomy/segmentectomy.
The hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy/se…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age ≥ 18 year
* Able to understand written and spoken Danish language
* PCS ≥20
* Signed written informed consent form.
* Patient planned to elective VATS lobectomy/segmentectomy
Exclusion Criteria:
* Patients undergoing systemic glucocorticoid or other immunosuppressive the…
Contacts