No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Prevention
Participants needed
48 (estimated)
Sponsor
University of Arizona · Other
Who this trial is looking for
This trial is looking for patients with non-small cell lung cancer who can participate in an exercise program before their surgery. Participants will meet certain health criteria and will be involved in understanding how exercise affects their recovery and tumor environment.
Are You a Good Fit for This Trial?
Rules you outMajor affective disorderAutoimmune diseasePregnancySevere anaphylactic reaction
You may be able to join if
I have lung cancer
I am considered low risk for exercise testing
You may not be able to join if
I am younger than 18 years old
I require physician approval before exercising
I have a body mass index greater than 30 kg/m2
My waist girth is greater than 102 cm if I'm a man or greater than 88 cm if I'm a woman
I have chronic or serious arthritis
I have been bedridden in the past three months
I have had a common illness in the past 6 weeks
I have HIV, hepatitis, or a history of stroke
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
There is increased interest and knowledge about the lung cancer tumor microenvironment (TME). Investigators hypothesize that patients with better baseline physiologic health will have better post-operative outcomes and that strenuous exercise will alter the TME and genetic make-up of the tumor, improving the tumor immune response. Investigators aim to identify the peri-operative and clinical outco…
There is increased interest and knowledge about the lung cancer tumor microenvironment (TME). Investigators hypothesize that patients with better baseline physiologic health will have better post-operative outcomes and that strenuous exercise will alter the TME and genetic make-up of the tumor, improving the tumor immune response. Investigators aim to identify the peri-operative and clinical outcomes that differ based on pre-operative VO2max, HRV and resting heart rate following resection of early-stage lung cancer. The physiologic states that are individual and measurable with wearable devices include but are not limited to VO2max, heart rate variability (HRV), and average resting heart rate. Investgators hypothesize that a patient's pre-operative physiologic function with higher VO2max, HRV and lower resting heart rate will be associated with improved peri-operative and post-operative outcomes. Second, investigators will compare alterations in TME based on targeted pre-operative exercise (60-80% of their VO2 max for 75min/week x2 weeks) compared to normal activity adults following resection of early-stage lung cancer. Investigators hypothesize that strenuous exercise in the pre-operative period will impact the TME by increasing levels of cytokines.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* lung cancer
* low risk for submaximal exercise testing in accordance with the risk stratification guidelines published by the American Heart Association and the American College of Sports Medicine (AHA/ACSM criteria).
Exclusion Criteria:
* younger than 18 years of age
* sele…
Inclusion Criteria:
* lung cancer
* low risk for submaximal exercise testing in accordance with the risk stratification guidelines published by the American Heart Association and the American College of Sports Medicine (AHA/ACSM criteria).
Exclusion Criteria:
* younger than 18 years of age
* select a condition on the ACSM-AHA pre-exercise screening questionnaire indicating that physician approval is required prior to exercise
* body mass index of \>30 kg/m2
* waist girth of \>102cm for men and \>88cm for women
* have chronic/debilitating arthritis
* have been bedridden in the past three months
* have common illness (i.e. colds) within the past 6-weeks
* HIV
* hepatitis
* history of stroke
* major affective disorder
* autoimmune disease
* pregnancy or are breast-feeding
* history of severe anaphylactic reaction to an allergen
* present with more than one of the following CVD risk factors: family history of myocardial infarction, coronary revascularization, or sudden death before 55 years of age in father or other male first-degree relative or before 65 years of age in mother or other female first-degree relative
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