Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans
Recruiting
Phase 1Interventional Study
Healthy Adults
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
23 – 90
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Prevention
Participants needed
24 (estimated)
Sponsor
Minicircle · Industry
Who this trial is looking for
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The purpose of this study is to investigate the safety and efficacy of a gene therapy for Klotho, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of the Klotho gene therapy.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Participant is open to morphological change
* If female, participant agrees to maintain contraception
* If female, participant agrees to take a pregnancy test
* If female, participant agrees to a pregnancy waiver
Exclusion Criteria:
* Women of childbearing potential who are …
Inclusion Criteria:
* Participant is open to morphological change
* If female, participant agrees to maintain contraception
* If female, participant agrees to take a pregnancy test
* If female, participant agrees to a pregnancy waiver
Exclusion Criteria:
* Women of childbearing potential who are unwilling or unable to use effective contraception for the duration of the study
* History of cancer diagnosis
* Preexisting medical issues that may be exacerbated by the treatment
* Has received any gene therapy within the past 12 months
* Unwilling or unable to provide written informed consent
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