No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
9 – 17
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
140 (estimated)
Sponsor
Washington University School of Medicine · Other
Who this trial is looking for
This trial is looking for kids aged 9-17 with juvenile arthritis or healthy kids to understand their pain. Participants will complete questionnaires and may provide saliva or blood samples during a 2.5-hour session.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 9 and 17 years old
I can understand and complete surveys
I speak English
I have been diagnosed or suspected of having juvenile arthritis
I am healthy and not in the juvenile arthritis group
You may not be able to join if
I am pregnant or breastfeeding
I have a chronic pain condition
I have a psychiatric condition like ADHD, anxiety, or depression
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Juvenile idiopathic arthritis (JIA) is the most common rheumatologic disease in children. The main symptoms of JIA, which are often the primary focus of treatment, include joint swelling, stiffness, and tenderness. Additional symptoms can include malaise, fatigue, and pain. However, the exact mechanisms contributing to pain are not yet fully understood. Participants will complete a 2.5-hours study…
Juvenile idiopathic arthritis (JIA) is the most common rheumatologic disease in children. The main symptoms of JIA, which are often the primary focus of treatment, include joint swelling, stiffness, and tenderness. Additional symptoms can include malaise, fatigue, and pain. However, the exact mechanisms contributing to pain are not yet fully understood. Participants will complete a 2.5-hours study session.
In the study session, psychophysical assessments of thermal and pressure stimuli will be performed. In addition, demographic, social, pubertal maturation, and behavioral and psychological factors will be collected via questionnaires. A saliva sample and/or blood draw may occur for the analysis of various immune factors and sex hormones. If a joint aspiration is done as part of their standard of care, we will request a sample of the synovial fluid for analyses of immune, hormonal and/or genetic factors. Participants will have the option to participate in additional optional follow-up study visits (every 3 months, up to 1 year) and to complete monthly surveys asking about their juvenile arthritis.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Age between 9-17
2. Males and females
3. English speakers
4. Able to complete surveys and understand study instructions
5. Juvenile arthritis group: diagnosed or suspected of juvenile arthritis
6. Control group: healthy
Exclusion Criteria:
1. Pregnancy or breastfeeding
2. (…
Inclusion Criteria:
1. Age between 9-17
2. Males and females
3. English speakers
4. Able to complete surveys and understand study instructions
5. Juvenile arthritis group: diagnosed or suspected of juvenile arthritis
6. Control group: healthy
Exclusion Criteria:
1. Pregnancy or breastfeeding
2. (Control Group) Diagnosed with a chronic pain condition
3. (Control Group) Diagnosed with psychiatric condition including ADHD, anxiety, depression, etc.
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