Brenipatide vs Placebo for Uncontrolled Severe Asthma

A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

Recruiting Phase 2 Interventional Study
Asthma
Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 75
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
531 (estimated)
Sponsor
Eli Lilly and Company · Industry
Who this trial is looking for

This trial is looking for adults with moderate to severe asthma who have trouble controlling their symptoms. Participants will receive either the study drug, brenipatide, or a placebo over about 65 weeks.

Are You a Good Fit for This Trial?
Rules you out Chronic respiratory infectionBronchiectasisPulmonary fibrosisAllergic bronchopulmonary aspergillosisEmphysemaChronic bronchitisEosinophilic granulomatosis with polyangiitisChronic obstructive pulmonary disease

You may be able to join if

  • I have been diagnosed with asthma.
  • I have used asthma controller medication for at least 12 months.
  • I have an asthma control questionnaire score of 1.5 or higher on 2 out of 3 visits.
  • I had one severe asthma attack treated with glucocorticoids in the last year.

You may not be able to join if

  • I have a diagnosis of occupational asthma.
  • I have a serious lung condition other than asthma.
  • I have a current or recent active infection.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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Answer a few quick questions to see if you may meet the eligibility requirements.

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About This Trial

The purpose of this study is to assess the safety and efficacy of brenipatide at different dose levels compared with placebo in participants with moderate-to-severe asthma. Study participation will last approximately 65 weeks, including screening, treatment, and follow-up periods.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Physician-diagnosed asthma who have received a physician-prescribed asthma controller medication for at least 12 months prior to screening visit. * Participants must have an asthma control questionnaire-6 (ACQ-6) score of ≥1.5 on 2 out of 3 visits before randomization. * Histo…
Contacts

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

317-615-4559

LillyTrials@Lilly.com

CONTACT

Physicians interested in becoming principal investigators please contact

clinical_inquiry_hub@lilly.com

CONTACT