Impact of Phenylalanine Elevations on Brain and Cognition in Adult PKU Carriers
Recruiting
N/A
Interventional Study
Carrier of Phenylketonuria
Healthy
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 60
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 36 (estimated)
- Sponsor
- University of Missouri-Columbia · Other
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
The goal of this clinical trial is to advance our understanding of the cognitive and neurophysiologic sequelae associated with suboptimal phenylalanine (Phe) metabolism in heterozygous carriers of phenylketonuria (PKU). The main questions it aims to answer are:
* Do PKU carriers experience prolonged elevations in brain Phe levels following oral ingestion of dietary Phe?
* Do PKU carriers experien…
Trial Locations
Loading…
Loading trial locations…
Eligibility Criteria
Inclusion Criteria:
* Age 18-60 years
* For the PKU carrier group: Individuals who are the parent of an individual with PKU or who are otherwise have confirmed PKU carrier status (e.g., a sibling of someone with PKU who has had genetic testing done)
* For the non-carrier group: Individuals who do n…
Contacts