A Study to Assess the Relative Bioavailability of Different Subcutaneous Formulations ofAZD6234
Recruiting
Phase 1Interventional Study
Healthy Participants
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 55
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
21 (estimated)
Sponsor
AstraZeneca · Industry
Who this trial is looking for
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This study in healthy volunteers aims to compare blood levels and side effects after administration of different formulations of AZD6234.
This study will take place at one site in Nottingham, United Kingdom, and will enrol 21 healthy men and women aged 18-55 years.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Healthy males or non-pregnant, non-lactating females aged 18 to 55 years inclusive
* BMI of 25.0 to 35.0 kg/m2 inclusive and weight ≥50 kg
Exclusion Criteria:
* History of any clinically important disease or disorder
* History or presence of clinically significant cardiovasc…
Inclusion Criteria:
* Healthy males or non-pregnant, non-lactating females aged 18 to 55 years inclusive
* BMI of 25.0 to 35.0 kg/m2 inclusive and weight ≥50 kg
Exclusion Criteria:
* History of any clinically important disease or disorder
* History or presence of clinically significant cardiovascular, renal, hepatic, dermatological, respiratory, neurological, psychiatric or gastrointestinal disorder including a history of pancreatitis or gall stones
* Any clinically significant illness, medical/surgical procedure, or trauma within 4 weeks of the planned first dosing day
* Clinically significant abnormal clinical chemistry, haematology, coagulation or urinalysis
* Any clinically significant abnormal findings in vital signs
* Any clinically significant abnormalities on 12-lead ECG
* HbA1c ≥6.5% (≥48 mmol/mol)
* Evidence of renal impairment
* Females who are pregnant or lactating.
* Any participant who has received an amylin analogue containing preparation within the last 30 days or 5 half-lives of the drug (whichever is longer)
* Participants who report to have previously received AZD6234.
* Use of any prescribed or non-prescribed medication
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