Oral Methadone in Cardiac Surgery
Recruiting
Phase 4
Interventional Study
Pain, Postoperative
Anesthesia
Cardiac Surgery
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 100 (estimated)
- Sponsor
- Mayo Clinic · Other
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About This Trial
The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
• Undergoing elective cardiac surgery
Exclusion Criteria:
* Chronic pain requiring opioid medications as an outpatient
* Opioid use disorder on medication assistance treatment
* Prolonged QTc \>500ms
* Chronic kidney disease with eGFR \< 30mL/min
* Documented cirrhosis
* Intol…
Contacts