No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
40 (estimated)
Sponsor
VA Office of Research and Development · Federal
Who this trial is looking for
This trial is looking for Veterans with chronic spinal cord injuries who want to explore new rehabilitation techniques. Participants will help researchers understand how to improve movement and quality of life using electrical stimulation methods.
Are You a Good Fit for This Trial?
You may be able to join if
I can read and understand study information.
I have a spinal cord injury that happened more than 1 year ago.
I can follow simple commands in English.
You may not be able to join if
I have conditions that prevent the use of electrical stimulation.
I have significant neurological issues that could affect test results.
I had major disabilities before my spinal cord injury.
I have visual or hearing problems that limit my participation.
I am pregnant.
I have serious psychiatric conditions that affect my understanding.
I have chronic pain that prevents me from having an MRI or doing exercises.
I have frequent, severe muscle spasms that prevent me from having an MRI or doing exercises.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Chronic spinal cord injury (SCI) is a debilitating disorder in Veterans and the broader U.S. population that does not have a cure. Veterans with severe SCI demonstrate permanent loss of sensory and motor function below their injury resulting in decreased quality of life and independence. Recently, electrical spinal neuromodulation has emerged as a potential approach to restore voluntary motor func…
Chronic spinal cord injury (SCI) is a debilitating disorder in Veterans and the broader U.S. population that does not have a cure. Veterans with severe SCI demonstrate permanent loss of sensory and motor function below their injury resulting in decreased quality of life and independence. Recently, electrical spinal neuromodulation has emerged as a potential approach to restore voluntary motor function and locomotion in persons with chronic SCI. However, spinal neuromodulation has yet to translate to clinical use due to small sample sizes in research studies and a lack of information on which patients would benefit. Here, the investigators propose a novel approach to evaluate the priorities and barriers faced by Veterans with SCI to use spinal neuromodulation, understand the neural connections remaining in Veterans with severe SCI, and determine potential functional improvements using non-invasive spinal neuromodulation technology. This research represents the first step towards deploying techniques that could dramatically improve function and quality of life for Veterans with SCI.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* All participants must be able to independently read and understand study information materials necessary to ensure informed consent
* All participants must have a chronic spinal cord injury occurring \>1 year prior to study enrollment
* Ability to follow simple commands in Eng…
Inclusion Criteria:
* All participants must be able to independently read and understand study information materials necessary to ensure informed consent
* All participants must have a chronic spinal cord injury occurring \>1 year prior to study enrollment
* Ability to follow simple commands in English
Exclusion Criteria:
* Contraindications to the use of external magnetic or electrical stimulation (e.g., epilepsy, intracranial metal, implanted electrosensitive device, etc.)
* Significant neurological comorbidities that may affect neurophysiological recordings
* Functional disability prior to spinal cord injury
* Visual or auditory disorders limiting ability to participate in study procedures
* Pregnancy
* Primary psychiatric disorders or dissociative mental symptoms that impair informed consent
* Significant chronic pain that may preclude an magnetic resonance imaging (MRI) scan or performing neurorehabilitation exercises
* Frequent and significant spasticity that may preclude an MRI scan or neurorehabilitation exercises
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