The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
Recruiting
Observational Study
Chronic Kidney Disease
Kidney Transplant
Coronary Microvascular Dysfunction (CMD)
Inflammation
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 80 (estimated)
- Sponsor
- Brigham and Women's Hospital · Other
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About This Trial
People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol. One early sign is reduced blood flow in the tiny vessels that supply the heart, measured by a positron emission tomography (PET) scan using a marker called myocardial flow reserve (MFR). In…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Renal transplant candidate on the waitlist
* Age greater or equal to 45 years, or if 18-44 years of age on dialysis for 5 years or more
Exclusion Criteria:
* Left ventricular ejection fraction (LVEF) \< 40%
* History of coronary artery bypass grafting (CABG)
* History of hea…
Contacts