Sex Differences in Neurobehavioral Response to THC
Recruiting
Phase 2
Interventional Study
Cannabis Use Disorder
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 21 – 45
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 40 (estimated)
- Sponsor
- Medical University of South Carolina · Other
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About This Trial
This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 21-45
* DSM-5 criteria for CUD
* Cannabis use ≥4 days/week
* THC-positive urine
* BMI 18-30
* Regular menstrual cycle (females)
* Willingness to use non-hormonal birth control (females)
Exclusion Criteria:
* Lifetime psychotic or bipolar disorder
* Recent drug use other …
Contacts
No contact information available.