Splicing-based Predictive Learning for Individual Chemotherapy Evaluation in Colorectal Cancer
Recruiting
Observational Study
Colorectal Cancer
Colorectal Cancer Recurrent
Colorectal Cancer Stage II
Colorectal Cancer Stage III
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 – 80
- Sex
- Any
- Study type
- Observational
- Participants needed
- 200 (estimated)
- Sponsor
- City of Hope Medical Center · Other
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About This Trial
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. Although adjuvant chemotherapy improves survival after curative resection, its efficacy varies widely among patients. The absence of reliable predictive biomarkers often leads to overtreatment or undertreatment.
This study aims to develop a machine learning-based predictive model for adjuvant chemothe…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Histologically confirmed stage II-III colorectal cancer (TNM classification, 8th edition)
* Received standard adjuvant chemotherapy after curative resection
* Availability of tumor tissue (FFPE or frozen) before chemotherapy
* Sufficient clinical data for outcome analysis (rec…
Contacts