Examining a Novel Gastrointestinal Intervention to Negate Environmental Toxicants (ENGINE)
Recruiting
Phase 1
Phase 2
Interventional Study
Toxicant Exposure
Firefighter
Occupational Exposure to Chemicals
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Male
- Trial phase
- Phase 1/2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 50 (estimated)
- Sponsor
- University of California, San Francisco · Other
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About This Trial
This randomized, placebo-controlled crossover trial will test the feasibility and acceptability of using colesevelam in male firefighters with high per- and polyfluoroalkyl substances (PFAS) exposure. This trial will also explore whether colesevelam lowers blood PFAS levels and urine environmental toxicant and mold mycotoxin levels.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Male firefighter, active or retired
* California resident
* Age 18 or older
* English-speaking
* Access to a reliable internet connection
* Willing to attend 3 in-person study visits in the San Francisco Bay Area over about 6.5 months
* Willing to receive weekly text message r…
Contacts