PF-08634404 with Cancer Medicines for Advanced Lung Cancer
Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
Recruiting
Phase 1
Phase 2
Interventional Study
Advanced/Metastatic Non-Small Cell Lung Cancer
Carcinoma, Non-Small Cell Lung
Non-Small Cell Lung Cancer
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 1/2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 162 (estimated)
- Sponsor
- Pfizer · Industry
Who this trial is looking for
This trial is looking for people with advanced lung cancer. Participants will receive a new medicine called PF-08634404 along with other cancer treatments at a clinic.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years or older
- I have advanced non-small cell lung cancer
- I am not a candidate for surgery
- I have measurable disease based on medical checks
- I have a PD-L1 status available
- I have an Eastern Cooperative Oncology Group performance status of 0 or 1
- I have adequate organ function
You may not be able to join if
- I have known gene changes for which there are first-line therapies
- I had another cancer within the last 2 years
- I have active brain or spinal cord lesions
- I have leptomeningeal disease
- I have active autoimmune diseases needing treatment in the last 2 years
- I received previous systemic treatment for advanced lung cancer
- I received prior immunotherapy or specific therapies recently
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
This study is being done to learn more about a new medicine called PF-08634404 and how it works when used with other cancer medicines in people who have advanced solid tumors. An advanced solid tumor is a type of cancer that has spread beyond its original location and cannot be removed by surgery or cured with standard treatments.
To join in the study, participants must:
* Be 18 years or older
*…
Trial Locations
Loading…
Loading trial locations…
Eligibility Criteria
Inclusion Criteria:
* Pathologically confirmed locally advanced (Stage IIIB/IIIC) or metastatic (Stage IV) squamous or non-squamous NSCLC and are not a candidate for complete surgical resection and curative concurrent/sequential chemoradiotherapy
* PD-L1 status available
* Part B only: PD-L1 ≥ TPS …
Contacts