B-PaLMZ for TB Meningitis
Recruiting
Phase 2
Interventional Study
Tuberculous Meningitis
HIV
Meningitis
TB - Tuberculosis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 240 (estimated)
- Sponsor
- David Boulware · Other
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About This Trial
This two-stage study will compare consented research participants with tuberculous meningitis receiving BPaLMZ to controls receiving SOC of rifampicin (R), isoniazid (H), pyrazinamide (Z), and ethambutol (E), known as RHZE.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* First Episode definite or probable TBM with physician intent to treat
* Age ≥18 years
* Provision of Informed Consent by participant or surrogate
* Living with HIV
* Weight \> 35kg, estimate or measured
Exclusion Criteria:
* Additional active and confirmed CNS infection
* Kn…
Contacts