Effect of Ev.FV on Wound Healing in Dystrophic Epidermolysis Bullosa

Inclusion Criteria: * DEB participants determined by electron microscopy, or genetic testing. Individuals with severe DEB (eg, RDEB patients with an absence of collagen VII) and milder forms of DEB (eg, RDEB patients with reduced levels of collagen VII) will be eligible. * People with one or more active wounds (each between 10 and 50 square centimeters on the arms, legs or trunk.) * Participants must be willing to comply with the requirements of the protocol and have consent to participate in the project. * Participants must be negative in the urine drug screening visit. Exclusion Criteria: * Participants with clinical evidence of systemic infection. * Participants have a history of bone marrow transplantation. * Participants must have evidence of autoimmune disease, including insulin-dependent diabetes. * Participant has evidence of significant wound healing prior to treatment (ie, wound closure ≥ 20% during treatment at the first observation period). * Participant has a severe medical condition, such as malignancy (including skin cancer), life expectancy less than 2 years, which limits movement to the clinical center. * Participants have a current history of alcohol or substance abuse or a history of alcohol or substance abuse that requires treatment in the past 12 months. * People participating in the screening should have a positive hepatitis and human immunodeficiency virus (HIV) test result. * Women who are pregnant, lactating or planning to become pregnant during the study * Women who are of reproductive age and use birth control pills.