7-Day Vonoprazan, High-Dose Amoxicillin, and Bismuth Therapy
Recruiting
Phase 4
Interventional Study
Helicobacter Pylori
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 70
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 316 (estimated)
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University · Other
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About This Trial
The 2024 American College of Gastroenterology (ACG) Clinical Guideline recommends a 14-day vonoprazan-amoxicillin (VA) regimen, consisting of vonoprazan 20 mg twice daily with amoxicillin 1000 mg three times daily, as a first-line treatment for Helicobacter pylori (H. pylori) infection.
Our previous study on regimen optimization showed that vonoprazan 20 mg twice daily combined with amoxicillin 1…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Aged 18 to 70 years, regardless of sex.
2. Helicobacter pylori infection confirmed by ¹³C or ¹⁴C urea breath test within 1 month before enrollment.
3. Chronic gastritis with H. pylori infection confirmed by endoscopy within 3 months, meeting the indications for eradication th…
Contacts