Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia

Recruiting Phase 2 Interventional Study
Hypertension
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About This Trial
The goal of this clinical trial is to determine if the medication eplerenone yields greater improvements in coronary microvascular function than chlorthalidone in women who experienced preeclampsia during pregnancy and subsequently developed chronic hypertension. The main Aims are: * To test the hypothesis that, in women with prior preeclampsia, current chronic hypertension, and concentric LV rem…
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Eligibility Criteria
Inclusion Criteria: * Female with a history of preeclampsia (defined by ACOG criteria) in a singleton pregnancy without pre-gestational chronic hypertension. * Current chronic hypertension (stage 1 or greater). * Evidence of concentric left ventricular (LV) remodeling, defined as relative LV wall t…
Contacts

Pearl Lee, MSc

617-721-7783

plee23@mgh.harvard.edu

CONTACT