Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome
Recruiting
Phase 3
Interventional Study
Down Syndrome
Autonomic Dysfunction
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 50
- Sex
- Any
- Trial phase
- Phase 3
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 200 (estimated)
- Sponsor
- University of Colorado, Denver · Other
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About This Trial
Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with widespread organ dysfunction, including abnormalities in the autonomic nervous system (ANS). The ANS regulates critical functions such as heart rate (HR) and blood pressure (BP), both essential for maintaining homeostasis and supporting physical activity. Individuals with DS often exhibit blunted HR re…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* 18-50 yrs old and apparently healthy individuals
* Ability to understand the study and give assent to participate
* Has a study partner who can attend all visits for the individuals with DS, and answer questionnaires, provide consent when necessary
* Corrected or non-existent …
Contacts