The present study will investigate whether the combined use of lung and brain ultrasonography is useful in selecting the optimal positive end-expiratory pressure in mechanically ventilated critically ill patients with acute respiratory distress syndrome and acute brain injury, aiming at an individualized, brain-protective ventilation strategy.
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Eligibility Criteria
Inclusion Criteria:
* Age ≥ 18 years
* Severe acute brain injury (e.g., traumatic brain injury, subarachnoid hemorrhage, intracerebral hemorrhage, acute ischemic stroke)
* Development of ARDS (according to Berlin criteria) within the first 10 days of ICU admission
Exclusion Criteria:
* Severe chr…
Inclusion Criteria:
* Age ≥ 18 years
* Severe acute brain injury (e.g., traumatic brain injury, subarachnoid hemorrhage, intracerebral hemorrhage, acute ischemic stroke)
* Development of ARDS (according to Berlin criteria) within the first 10 days of ICU admission
Exclusion Criteria:
* Severe chronic brain diseases
* Brain tumor or central nervous system (CNS) infection
* Severe chronic pulmonary or cardiovascular disease
* Severe coagulopathy
* Undergoing decompressive craniectomy
* Lack of invasive neuromonitoring
* Withdrawal of life-sustaining treatment
* Poor acoustic window in ultrasound
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