Anabolic Response to Beef vs Plant Protein in (Pre)Frail Older Adults Using a Novel Stable Isotope Pulse Method
Recruiting
N/AInterventional Study
Protein Metabolism
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
65 – 95
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
60 (estimated)
Sponsor
Texas A&M University · Other
Who this trial is looking for
This trial is looking for older adults aged 65-95 to compare how their bodies respond to beef protein versus plant protein. Participation involves measuring how well your body uses these proteins after a meal.
Are You a Good Fit for This Trial?
Rules you outDementiaHepatitis AHepatitis BHepatitis C
You may be able to join if
I am 65 to 95 years old
I can walk and get up without help or with a walking aid
I am willing to lie down in bed for up to 6 hours
I have not taken supplements or medications affecting protein metabolism in the last 4 weeks
I can follow the study instructions
You may not be able to join if
I have a BMI less than 17 or greater than 35
I have an active chronic disease like diabetes or heart disease
I had a fever in the last 3 days
I have liver cirrhosis
I have a history of untreated metabolic disease
I am currently pregnant or may be pregnant
I am dependent on alcohol or drugs
I have an allergy to soy or beef
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Frailty is a common clinical syndrome in older adults that increases the risk for poor health outcomes including falls, disability, hospitalization, and mortality. Previous research showed increased protein needs and reduced anabolic response to meals in older adults, indicating the need for proteins with a high anabolic capacity to prevent and attenuate physical and cognitive health decline throu…
Frailty is a common clinical syndrome in older adults that increases the risk for poor health outcomes including falls, disability, hospitalization, and mortality. Previous research showed increased protein needs and reduced anabolic response to meals in older adults, indicating the need for proteins with a high anabolic capacity to prevent and attenuate physical and cognitive health decline throughout the frailty cycle. Recently, more people have chosen to eliminate animal (i.e., beef) products from their diets which is concerning because of beef's anabolic properties due to high essential amino acid (EAA) levels and many other positive health effects. The Researchers' recently developed stable isotope amino acid pulse method enables measurement of the true intracellular anabolic response to a meal and bioavailability of food-derived amino acids. The research objective is to examine differences in the anabolic response and bioavailability of individual EAA and non-essential amino acids (NEAA) in beef as compared to plant protein in older adults with and without (pre-)frailty.
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Eligibility Criteria
Inclusion criteria:
* Age 65-95 years old
* Ability to walk, sit down, and stand up (independently or with walking assistance device)
* No recent use (\< 4 weeks prior to start of the study) of dietary supplements and medication influencing protein and amino acid metabolism (e.g., antibiotics, oral…
Inclusion criteria:
* Age 65-95 years old
* Ability to walk, sit down, and stand up (independently or with walking assistance device)
* No recent use (\< 4 weeks prior to start of the study) of dietary supplements and medication influencing protein and amino acid metabolism (e.g., antibiotics, oral corticosteroids)
* Willingness to lay supine in bed for up to 6 hours
* Willingness and ability to comply with the protocol
Exclusion criteria
* Presence of malnutrition (BMI \< 17 kg/m2), 2). BMI \>35 kg/m2 to avoid weight-related metabolic disturbances,
* Established diagnosis and active treatment of chronic disease: Insulin-dependent diabetes mellitus, active malignancy, heart disease, kidney disease, liver disease, HIV/AIDS, Asthma (moderate to severe), Hep (A, B, or C)
* History of untreated metabolic disease including hepatic or renal disorder
* Presence of fever within the last 3 days
* Cirrhosis of liver
* Diagnosis of dementia, neurodegenerative disease (e.g., Alzheimer's disease, Parkinson's disease, Huntington's chorea, frontotemporal dementia).
* (Possible) pregnancy
* Presence of acute illness or metabolically unstable chronic illness
* Active dependence on alcohol or drugs
* Newly prescribed long-term oral corticosteroids
* Planned elective surgery requiring 2 or more days of hospitalization during the entire study
* Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject
* Already enrolled in another clinical trial
* Any condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient
* Known allergy to any of the components of the feeding (soy, beef)
* Established daily diet of vegetarian/vegan composition
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