No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
8 (estimated)
Sponsor
Pennington Biomedical Research Center · Other
Who this trial is looking for
This trial is looking for adults with Alzheimer's Disease to see if weekly insulin injections can help with their thinking skills and how their body uses sugar. Participants will receive insulin weekly for 6 months and complete some memory tests.
Are You a Good Fit for This Trial?
You may be able to join if
I have an MMSE score less than 25
You may not be able to join if
I take daily medication for anxiety like benzodiazepines
I am an infant, child, or teenager
I am pregnant
I am a prisoner
I have a condition that makes me unsuitable for this study
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease. It will also provide information about the safety and feasibility of this intervention.
The main questions it aims to answer are:
Does the intervention improve insulin sensitivity (how the body u…
The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease. It will also provide information about the safety and feasibility of this intervention.
The main questions it aims to answer are:
Does the intervention improve insulin sensitivity (how the body uses glucose)?
Does the intervention improve cognition, measured by the Montreal Cognitive Assessment (MoCA) and the Revised Memory and Behavior Problems Checklist (RMBPC)?
What changes occur in brain glucose uptake (FDG-PET)?
Participants will:
Receive the intervention once a week for 6 months, with each session lasting up to 2 hours
Complete cognitive assessments. Adverse events will be assessed throughout the study.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Mini Mental State Examination (MMSE) score \< 25
Exclusion Criteria:
* On daily medication for the specific treatment of anxiety including benzodiazepines.
* An infant, child, or teenager
* A pregnant woman
* A prisoner
* Having any condition that impedes testing of the stud…
Inclusion Criteria:
* Mini Mental State Examination (MMSE) score \< 25
Exclusion Criteria:
* On daily medication for the specific treatment of anxiety including benzodiazepines.
* An infant, child, or teenager
* A pregnant woman
* A prisoner
* Having any condition that impedes testing of the study hypothesis or are otherwise deemed to be unsuitable (determined by the investigative team).
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