Integrated Cf-miRNA and Exosomal miRNA Signature for Early Detection of Esophageal Squamous Cell Carcinoma
Recruiting
Observational Study
ESCC
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 600 (estimated)
- Sponsor
- City of Hope Medical Center · Other
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About This Trial
Esophageal squamous cell carcinoma (ESCC) remains a highly lethal cancer worldwide, largely due to late diagnosis. Current screening methods such as upper endoscopy are invasive, operator-dependent, and limited in their ability to detect early-stage lesions.
To address this clinical need, the SYNERGY study seeks to develop a non-invasive, blood-based biomarker assay that integrates cell-free micr…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adults age 18 to 90 years
* Histologically confirmed esophageal squamous cell carcinoma
* No prior systemic therapy before sample collection
* For control groups: absence of malignant disease
Exclusion Criteria:
* Lack of informed consent
* Inadequate sample volume or RNA qu…
Contacts