Research on ALS Biomarkers and Treatment Targets
Translating Single-cell Vulnerability Into Novel ALS Biomarkers and Therapeutic Targets: Towards a Liquid Nerve Biopsy
Recruiting
Observational Study
Amyotrophic Lateral Sclerosis (ALS)
Peripheral Neuropathies
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 400 (estimated)
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Other
Who this trial is looking for
This trial is looking for adults with Amyotrophic Lateral Sclerosis (ALS), including some at risk for developing the condition. Participants will help researchers understand ALS better and develop new ways to detect and treat it.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years old or older
- I have been diagnosed with ALS
- My ALS symptoms started less than 24 months ago
- I have a family member with ALS if I am at risk for it
You may not be able to join if
- My forced vital capacity (FVC) is less than 60%
- I have nutritional failure
- I have respiratory failure
- I have significant liver failure
- I have chronic kidney failure
- I have any major infections or metabolic issues that affect my health
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
The progress of ALS research and clinical practice is hampered by lack of effective biomarkers to monitor disease onset and progression. In response to this urgent need, we will integrate single-cell system biology approaches, histopathological and clinical data from precious human nerve biopsies collected from living ALS patients during the diagnostic workup and findings from innovative preclinic…
Trial Locations
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Eligibility Criteria
Inclusion Criteria for als patients:
* Age equal or over 18 years old
* ALS patients, diagnosed accordingly to the revised El Escorial Criteria
* Disease duration \<24 months from symptom onset.
Exclusion Criteria for als patients:
* FVC \<60%;
* nutritional or respiratory failure;
* significant …
Contacts
No contact information available.