THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins

* INCLUSION CRITERIA: To participate in this study, an individual must meet all of the following criteria: 1. Ability to provide informed consent. 2. Age 18-80 years. 3. Agreement to adhere to lifestyle considerations. 4. Ability to exclusively adhere to UPD and MPD during inpatient stay. 5. Ability to speak English. 6. Willing to allow storage of samples and data for future research. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Diagnosis of atopic (physician-diagnosed asthma, AD, food allergy, chronic hives), autoimmune, metabolic, or chronic infectious or inflammatory diseases. 2. Current or history of neoplastic disease within 5 years. 3. Use of medication(s) that may affect skin, GI, and/or airway symptoms and may have an effect on skin microbiome, GI microbiome (topical or oral antibiotic use may require 3-6 month delay in enrollment for gut microbiome repopulation, see #8), and/or serum cytokines (other than oral birth control, which is not exclusionary and is allowed during participation provided there is consistence use for 3-6 months prior to enrollment). 4. Current receipt of chemotherapy. 5. HIV, hepatitis B, or hepatitis C infection. 6. Receipt of any vaccine within 1 month prior to enrollment. 7. Receipt of oral antibiotics within 3-6 months prior to enrollment. 8. Use of topical, oral, or parental corticosteroids within 1 month prior to enrollment. 9. Participation in another treatment or intervention study within 3 months prior to enrollment. 10. Currently pregnant or lactating. 11. Currently smoking or vaping. 12. Any other condition or intercurrent illness deemed by the investigators to be of potential risk to the participant or validity of study results.