Nalbuphine Timing Effects on Hemodynamics and Analgesia in Elderly Patients
Recruiting
Phase 4
Interventional Study
Postoperative Pain, Acute
Hemodynamics
Total Knee Arthroplasty (TKA)
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 65 – 90
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Other
- Participants needed
- 162 (estimated)
- Sponsor
- Qianfoshan Hospital · Other
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About This Trial
In total knee arthroplasty (TKA), the use of a tourniquet and controlled hypotension is common. However, ischemia-reperfusion injury induced by the tourniquet and inappropriate controlled hypotension can lead to cardiac and cerebral damage in patients. Consequently, maintaining hemodynamic stability, ensuring adequate cerebral perfusion, and achieving controlled blood pressure during the periopera…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* All study participants voluntarily enrolled in the trial and provided written informed consent after being fully informed of the trial's purpose and significance
* Participants underwent unilateral total knee arthroplasty under general anesthesia
* Elderly participants (age ≥ …
Contacts