SBRT Plus Systemic Therapy vs Systemic Therapy Alone in BCLC C Hepatocellular Carcinoma

Recruiting Phase 2 Interventional Study
Hepatocellular Carcinoma BCLC Stage C Hepatocellular Carcinoma
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial. Healthy Volunteers Welcome You do not need to have the condition being studied to take part.
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At a Glance
Age
18 – 70
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
184 (estimated)
Sponsor
Shandong Cancer Hospital and Institute · Other
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About This Trial
This prospective, multicenter, phase II randomized controlled trial compares the efficacy and safety of SBRT combined with systemic therapy versus systemic therapy alone in BCLC stage C hepatocellular carcinoma (HCC). The primary objective is to compare overall survival (OS) between the two arms. Secondary objectives include progression-free survival (PFS), objective response rate (ORR), quality o…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Age 18-70 years. 2. Histologically or clinically diagnosed HCC per national guidelines. 3. BCLC stage C (CNLC IIIA/IIIB), including PVTT and/or extrahepatic metastases amenable to protocol procedures. 4. Child-Pugh class A or B (score ≤7). 5. At least one measurable lesion pe…
Contacts

Jinbo Yue, doctor

0531-67626442

jbyue@sdfmu.edu.cn

CONTACT