Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2
Recruiting
N/AInterventional Study
PASC Post Acute Sequelae of COVID 19Fatigue
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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At a Glance
Age
18 – 75
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
200 (estimated)
Sponsor
Hugo W. Moser Research Institute at Kennedy Krieger, Inc. · Other
Who this trial is looking for
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This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventually provide candidate mechanisms to target with pharmacological intervention and inform rehabilitative care for those individuals suffering from symptoms of fatigue in PASC.
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Eligibility Criteria
Inclusion Criteria:
* Age 18 to 75 years old.
* Have received a clinical diagnosis of post-acute sequelae of SARS-CoV-2 (PASC)/long COVID syndrome using the criteria specified by Thaweethai, et al., 2023 (JAMA). This symptom checklist provides a score based on the number and severity of symptoms. A…
Inclusion Criteria:
* Age 18 to 75 years old.
* Have received a clinical diagnosis of post-acute sequelae of SARS-CoV-2 (PASC)/long COVID syndrome using the criteria specified by Thaweethai, et al., 2023 (JAMA). This symptom checklist provides a score based on the number and severity of symptoms. An individual with a score \>12 is classified as having PASC.
* Currently experiencing Fatigue/Brain Fog as assessed with the Post-COVID symptom checklist and the PedsQL questionnaire.
Exclusion Criteria:
* Neurological disorders including, but not limited to, stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease, or any other neuromuscular disease (self-report).
* Diagnosed history of severe psychiatric diseases such as depression and schizophrenia (self-report).
* Congestive heart failure.
* Peripheral artery disease with claudication.
* Cancer.
* Pulmonary or renal failure.
* Unstable angina.
* Uncontrolled hypertension (more than 190/110 mmHg).
* Severe aphasia.
* Orthopedic or pain conditions.
* Have had exposure to metal or metal implants, due to the hazardous effects of the magnetic field.
* If on immunomodulatory therapy, they must have been on that therapy for at least 6 months before the start of the study.
Healthy age- and sex-matched controls for PASC - Exclusion criteria: Participants with a history of any of the following will be excluded from the study:
* Hospitalization due to SARS-CoV-2 infection.
* Neurological disorders including, but not limited to, stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease, or any other neuromuscular disease (self-report).
* Diagnosed history of severe psychiatric diseases such as depression and schizophrenia (self-report).
* Congestive heart failure.
* Peripheral artery disease with claudication.
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