Evaluation of the Safety, Tolerability and Pharmacokinetics of HY8931 in Healthy Adult Participants

Inclusion Criteria: 1. Male and female participants must be 18 to 45 years of age, inclusive, at the time of signing the informed consent. 2. Male and female participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, vital sign and 12-lead ECG. 3. Participants who are willing and able to comply with all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures. 4. BMI of 18 to 32 kg/m2; and a total body weight \>50 kg. 5. Capable of giving signed informed consent as described in Appendix 1, which includes compliance with the requirements and restrictions listed in the informed consent and in this protocol. Exclusion Criteria: 1. Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing). 2. Positive hepatitis B surface antigen (HBsAg), hepatitis B core antibody (HBcAb), or hepatitis C antibody or positive testing for HIV or syphilis at the screening visit. 3. History of allergic or anaphylactic reaction to a therapeutic drug. 4. History of recent active infections within 28 days prior to the screening visit. 5. Participants with a fever within 48 hours prior to dosing. 6. Positive QFT-G test. 7. History of recurrent bacterial infection (\>3 per year) or recurrent HSV infection. 8. The medications as listed in section 6.9.2 are exclusionary, all other medications and supplements allowed at investigator discretion. (Refer to Section 6.9 Prior and Concomitant Therapy for additional details). 9. Recent exposure to live vaccines within 28 days of the screening visit or plan to receive live vaccination during the trial. 10. Known exposure to anti-TL1A or IL23 or any type of anti-TL1A or anti-IL23 therapy. 11. Previous administration with an investigational drug within 90 days (or as determined by the local requirement) or 5 half-lives preceding the first dose of study intervention used in this study (whichever is longer). 12. A positive urine drug test. 13. A positive pregnancy test. 14. Screening supine BP ≥140 mm Hg (systolic) or ≥90 mm Hg (diastolic), following at least 5 minutes of supine rest. If BP is ≥140 mm Hg (systolic) or ≥90 mm Hg (diastolic), the BP should be repeated 2 more times and the average of the 3 BP values should be used to determine the participant's eligibility. 15. Baseline 12-lead ECG that demonstrates clinically relevant abnormalities that may affect participant safety or interpretation of study results (eg, baseline QTc interval\>450 msec, complete LBBB, signs of an acute or indeterminate-age myocardial infarction, ST-T interval changes suggestive of myocardial ischemia, second or third-degree AV block, or serious bradyarrhythmias or tachyarrhythmias). If the baseline uncorrected QT interval is \>450 msec, this interval should be rate corrected- using the Fridericia method and the resulting QTcF should be used for decision making and reporting. If QTc exceeds 450 msec, or QRS exceeds 120 msec, the ECG should be repeated 2 more times and the average of the 3 QTc or QRS values should be used to determine the participant's eligibility. Computer interpreted-ECGs should be overread by a physician experienced in reading ECGs before excluding participants. 16. Participants with ANY of the following abnormalities in clinical laboratory tests at screening, as assessed by the study specific-laboratory and confirmed by a single repeat test, if deemed necessary: * AST or ALT level \>1.5 × ULN; * Total bilirubin level \>1.5 × ULN; participants with a history of Gilbert's syndrome may have direct bilirubin measured and would be eligible for this study provided the direct bilirubin level is ≤ ULN; 17. History of alcohol abuse or binge drinking and/or any other illicit drug use or dependence within 6 months of Screening. Binge drinking is defined as a pattern of 5 (male) and 4 (female) or more alcoholic drinks in about 2 hours. As a general rule, alcohol intake should not exceed 14 units per week for male, 10 units per week for female (1 unit = 240 mL beer, 30 mL of 40% spirit or 90 mL of wine). And participants with \>5 cigarettes per week intake. 18. Blood donation (excluding plasma donations) of approximately 500 mL or more within 30 days prior to dosing. 19. History of sensitivity to heparin or heparin -induced thrombocytopenia 20. Unwilling or unable to comply with the criteria in the Lifestyle Considerations section of this protocol. 21. Investigator site staff or The sponsor employees directly involved in the conduct of the study, site staff otherwise supervised by the investigator, and their respective family members.