Safety and Efficacy of Klotho and Follistatin Gene Therapy
Recruiting
Early Phase 1Interventional Study
Healthy Adults
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
50 – 80
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Prevention
Participants needed
30 (estimated)
Sponsor
Minicircle · Industry
Who this trial is looking for
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The purpose of this study is to investigate the safety and efficacy of a combination klotho and follistatin gene therapy, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of this gene therapy.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adults aged 50 to 80 years
* General good health
* Willing to comply with all study-related procedures and visits
* Participant is open to morphological change
* If female, participant agrees to maintain contraception
* If female, participant agrees to take a pregnancy test
* …
Inclusion Criteria:
* Adults aged 50 to 80 years
* General good health
* Willing to comply with all study-related procedures and visits
* Participant is open to morphological change
* If female, participant agrees to maintain contraception
* If female, participant agrees to take a pregnancy test
* If female, participant agrees to a pregnancy waiver
Exclusion Criteria:
* Currently enrolled in another clinical trial
* History of cancer, autoimmune disease, or chronic kidney/liver disease
* Use of immunosuppressive therapy
* Pregnant or breastfeeding
* Women of childbearing potential who are unwilling or unable to use effective contraception for the duration of the study.
* Regular use of NMDA (N-methyl-D-aspartate) antagonists (i.e., memantine, ketamine, etc.)
* Regular use of antiplatelet medications (i.e., aspirin)
* Any medical or psychiatric condition that could interfere with participation or pose safety concerns
* Unwilling or unable to provide informed consent
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