Arestin with Scaling for Periodontitis in Diabetics
Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics
Recruiting
Early Phase 1
Interventional Study
Periodontitis, Diabetes Mellitus Type 2
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Early Phase 1
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 42 (estimated)
- Sponsor
- Case Western Reserve University · Other
Who this trial is looking for
This trial is looking for adults with type 2 diabetes and gum disease. Participants will receive a common gum treatment with an additional medication called Arestin to see if it helps improve their gum health and blood sugar control.
Are You a Good Fit for This Trial?
You may be able to join if
- I am at least 18 years old.
- I have been diagnosed with type 2 diabetes.
- My HbA1c is between 7.0% and 9.5%.
- I have moderate to severe periodontitis.
- I have at least 16 teeth.
- I have not had any periodontal treatment in the last 6 months.
You may not be able to join if
- I am allergic to minocycline or tetracycline.
- I cannot receive or tolerate local anesthesia.
- I cannot tolerate tooth cleaning with ultrasound instruments.
- I need IV sedation for scaling and root planing.
- I have used antibiotics in the past 3 months.
- I am pregnant or breastfeeding.
- I have a BMI of 40 or higher.
- I smoke or have poorly controlled health issues besides diabetes.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
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About This Trial
Periodontitis is a prevalent chronic inflammatory disease that exacerbates systemic inflammation and poses challenges for glycemic control in diabetic patients. While scaling and root planing (SRP) remains the cornerstone of periodontal therapy, adjunctive treatments such as Arestin (minocycline microspheres) have shown promise in enhancing clinical outcomes. This study aims to evaluate the impact…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Adults (≥18 years) with type 2 diabetes mellitus (HbA1c ≥ 7.0% and ≤9.5%)
2. Diagnosed with moderate to severe periodontitis (≥5 mm probing pocket depth in at least 6 distinct interproximal sites, on different teeth)
3. At least 16 teeth present
4. No periodontal treatment in…
Contacts