Quantitative Net Water Uptake as a Predictor of Functional Outcomes After Intravenous Thrombolysis in Acute Ischemic Stroke International Multicenter Observational Retrospective Study
Recruiting
Observational Study
Ischemic Stroke
Thrombolysis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 200 (estimated)
- Sponsor
- Sigmund Freud PrivatUniversitat · Other
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About This Trial
While the effectiveness of intravenous thrombolysis (IVT) decreases over time, patients show considerable variability in how quickly their ischemic core progresses. Quantitative net water uptake (NWU) has emerged as a biomarker indicating blood-brain barrier disruption and may better reflect the "tissue clock" than time alone. Low NWU is associated with favorable outcomes, whereas high NWU predict…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Acute ischemic stroke treated with intravenous thrombolysis
* Imaging with non-contrast cranial CT on admission
* Follow-up imaging with non-contrast cranial CT or MRI 12-24 hours after IVT
* Final Infarct volume \> 5ml
* ASPECTS available
Exclusion Criteria:
* Known use of …
Contacts