Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: a Multi-centre and Multi-modal Approach
Recruiting
Phase 3
Interventional Study
Parkinson's Disease (PD)
Freezing of Gait
Freezing of Gait Symptoms in Parkinson Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 3
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 60 (estimated)
- Sponsor
- Radboud University Medical Center · Other
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About This Trial
The goal of this clinical trial is to learn if the medication atomoxetine can reduce freezing of gait in people with Parkinson's disease. The main questions it aims to answer is:
Does atomoxetine reduce the frequency or severity of freezing of gait? What role does noradrenaline play in freezing of gait?
Researchers will compare atomoxetine to a placebo to see if atomoxetine can improve freezing …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Aged 18 years or older;
* Diagnosis of idiopathic PD according to MDS Diagnostic Criteria;
* Stabilised on optimal dopaminergic PD treatment for a minimum of four weeks prior to the baseline visit (Visit 1) and for the duration of the trial;
* Presence of FOG symptoms on a dai…
Contacts
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