Sac-TMT for Advanced Ovarian Cancer

A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)

Recruiting Phase 3 Interventional Study
Ovarian Neoplasms Ovarian Cancer
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Pivotal Trial This treatment is in the last trial phase before FDA approval. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

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At a Glance
Age
18 and older
Sex
Female
Trial phase
Phase 3
Study type
Interventional
Purpose
Treatment
Participants needed
900 (estimated)
Sponsor
Merck Sharp & Dohme LLC · Industry
Who this trial is looking for

This trial is looking for people with advanced ovarian cancer who have already received certain treatments. Participants will receive a treatment called sacituzumab tirumotecan to see if it helps keep the cancer from worsening.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have been diagnosed with advanced ovarian cancer.
  • I have completed surgery to remove cancer.
  • I have finished my first round of chemotherapy.
  • I have provided tumor tissue that has not been treated with radiation.
  • I have well-controlled HIV if I am HIV positive.
  • I have undetectable hepatitis B if I am HBsAg-positive.
  • I have undetectable hepatitis C if I have HCV history.

You may not be able to join if

  • I have non-epithelial cancers or low-grade tumors.
  • I have known active brain cancer or meningitis from cancer.
  • I have had severe eye disease.
  • I have ongoing inflammation in my bowel that needs medicine.
  • I have uncontrolled heart or blood vessel disease.
  • I have a history of lung problems that needed steroids.
  • I have received any cancer treatment besides my first chemotherapy.
  • I currently have an active infection that needs treatment.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial
Researchers are looking for new ways to treat ovarian cancer (OC). Current treatment for OC may start with surgery to remove as much of the cancer as possible. After surgery, people may receive chemotherapy. After chemotherapy, standard care options may include: * Maintenance treatment, which is used after another therapy to keep the cancer from growing, spreading, or coming back. Bevacizumab is …
Trial Locations
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Eligibility Criteria
The main inclusion criteria include but are not limited to the following: * Has diagnosis of FIGO 2014 Stage III or Stage IV, histologically confirmed epithelial ovarian, primary peritoneal, or fallopian tube carcinoma with one of the following histologies: high-grade serous, high-grade endometrioi…
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