The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction

Inclusion Criteria: * Age: Adults aged 21 years and older * Current Vaping Behavior: Daily or near-daily use (≥5 days/week or at least 20 days per month) of nicotine-containing e-cigarettes for at least the past 3 months. * Motivation and desire to quit as determined by all of the following three assessment tools: * Score of 4 or 5 on all 5-point Likert-type scale questions (see appendix) * Score of 6 or 7 on Motivation To Stop Scale (MTSS) (see appendix) * Participants must be classified in the Preparation stage of the Transtheoretical Model of behavior change (see appendix) * Saliva Cotinine level ≥ 10 ng/ml * Penn State Electronic Cigarette Dependence Index (PSECDI) of at least 4 and above * Willingness to participate in the study and all study requirements * Willingness to not use any other nicotine-containing products for the duration of the study * Ability to attend visits and provide informed consent Exclusion Criteria: * Mental Health Concerns with a score above the following thresholds: * PHQ-2 score ≥ 2 (see appendix) * GAD-2 score ≥ 2 (see appendix) * Use of Other Tobacco or Nicotine Products: * Use of any nicotine products except for vaping, including combustible tobacco (e.g., cigarettes) or other non-e-cigarette nicotine delivery systems within the past 30-days * Current Substance or alcohol Use Disorder: * Self-reported or medically diagnosed substance use disorder (excluding nicotine), unless in sustained remission (\>12 months). * Illicit drug use in the past 60 days * Screening positive for alcohol use disorder in past year * Medical Contraindications: * Any serious medical condition or medication that would contraindicate participation in a behavioral cessation trial (to be defined and assessed by study physician or PI). * Pregnant or breastfeeding * Symptomatic cardiovascular disease * Participation in another smoking/vaping cessation trial