No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Sex
Any
Study type
Observational
Participants needed
103 (estimated)
Sponsor
Tongji Hospital · Other
Who this trial is looking for
This trial is looking for patients with advanced bile duct or pancreatic cancer who have been in pain. Taking part involves receiving a pain management procedure and starting standard cancer treatment while being monitored for up to 2 years.
Are You a Good Fit for This Trial?
You may be able to join if
I have advanced bile duct or pancreatic cancer.
I have been experiencing cancer-related pain.
My pain score is 4 or higher for over a week.
I am scheduled to receive first-line cancer treatment.
My performance status is 0-2.
I have an estimated life expectancy of at least 3 months.
You may not be able to join if
I have had celiac plexus neurolysis before.
I have a bleeding disorder.
I have severe heart, liver, or kidney problems.
I have a local infection or an anatomical issue that prevents the procedure.
I have another condition that could make it unsafe for me to participate.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
This study is for patients with advanced bile duct or pancreatic cancer who are experiencing pain from their disease. The purpose of this research is to learn about the effects of combining a standard pain relief treatment (Celiac Plexus Block) with standard first-line cancer drugs.
Patients in this study will receive the Celiac Plexus Block procedure, which is intended to reduce pain, and will t…
This study is for patients with advanced bile duct or pancreatic cancer who are experiencing pain from their disease. The purpose of this research is to learn about the effects of combining a standard pain relief treatment (Celiac Plexus Block) with standard first-line cancer drugs.
Patients in this study will receive the Celiac Plexus Block procedure, which is intended to reduce pain, and will then begin their standard cancer medication regimen. Researchers will observe and compare how well this combined approach works to control pain and the cancer itself, and will monitor for any side effects. Participation in this study involves being followed by the research team for up to 2 years to track health outcomes.
The goal is to see if starting cancer treatment together with this specialized pain management technique is more helpful for patients compared to what is already known about the standard treatments alone.
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Histologically confirmed advanced biliopancreatic malignancy (including biliary tract cancer or pancreatic cancer).
* Cancer-related pain: Baseline Numeric Rating Scale (NRS) pain score ≥ 4 points for over 1 week, with plans to receive celiac plexus neurolysis (CPN).
* Schedul…
Inclusion Criteria:
* Histologically confirmed advanced biliopancreatic malignancy (including biliary tract cancer or pancreatic cancer).
* Cancer-related pain: Baseline Numeric Rating Scale (NRS) pain score ≥ 4 points for over 1 week, with plans to receive celiac plexus neurolysis (CPN).
* Scheduled to receive a first-line systemic treatment regimen (e.g., PD-1/PD-L1 inhibitor monotherapy or in combination with chemotherapy/targeted therapy).
* ECOG Performance Status of 0-2 and an estimated life expectancy of ≥ 3 months.
Exclusion Criteria:
* Previous history of celiac plexus neurolysis or ablation.
* Coagulation disorders (INR \> 1.5, platelet count \< 50 × 10⁹/L).
* Severe cardiac, hepatic, or renal insufficiency (Child-Pugh Class C, estimated glomerular filtration rate (eGFR) \< 30 mL/min, NYHA Class III-IV heart failure).
* Contraindications to celiac plexus block (e.g., local infection, anatomical variation).
* Any other condition that, in the investigator's judgment, would preclude safe participation in the study.
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.