Faecal Microbiota Transplant for Alzheimer's Disease
Alzheimer's Disease and Faecal Microbiota Transplantation -a Pilot Study
Recruiting
Phase 1Interventional Study
Alzheimer s DiseaseFaecal Microbiota Transplantation (FMT)
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
10 (estimated)
Sponsor
University Hospital of North Norway · Other
Who this trial is looking for
This trial is looking for people with mild to moderate Alzheimer's disease. Participants will receive a treatment called faecal microbiota transplantation to see if it is safe and helpful for their condition.
Are You a Good Fit for This Trial?
Rules you outMajor psychiatric disorderDecompensated heart diseaseMalignancyInflammatory bowel diseaseImmunocompromised status
You may be able to join if
I have been diagnosed with Alzheimer's disease.
I have mild to moderate Alzheimer's dementia.
I can give informed consent.
You may not be able to join if
I have a contraindication for colonoscopy examination.
I have a contraindication for Magnetic Resonance Imaging (MRI).
I have a life expectancy of less than one year.
I am considered clinically frail.
I have a history of seizure disorder.
I have a history of brain tumor or intracranial bleed.
I have a major psychiatric disorder.
I am currently using anticoagulant treatment.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The goal of this study is to assess the feasibility and safety of faecal microbiota transplantation for Alzheimer's disease.
Trial Locations
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City
State
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Status
Eligibility Criteria
Inclusion Criteria:
* Alzheimer's dementia mild to moderate stage
* Presence of Alzheimer pathology core 1 biomarkers as defined by National Institute on Aging-Alzheimer's Association (NIA-AA) criteria (2024)
* Capable of giving informed consent
Exclusion Criteria:
* Contraindications for colonos…
Inclusion Criteria:
* Alzheimer's dementia mild to moderate stage
* Presence of Alzheimer pathology core 1 biomarkers as defined by National Institute on Aging-Alzheimer's Association (NIA-AA) criteria (2024)
* Capable of giving informed consent
Exclusion Criteria:
* Contraindications for colonoscopy examination
* Contraindications for Magnetic Resonance Imaging (MRI)
* Life expectancy \< 1 year
* Clinical frailty scale 7 or more
* History of seizure disorder
* History of brain tumour or intracranial bleed
* Major psychiatric disorder such as schizophrenia, bipolar disorder, or major depressive disorder
* Alcohol or substance abuse
* Decompensated heart disease
* Malignancy
* Current use of anticoagulant treatment (dual acting oral anticoagulant or warfarin)
* Pregnant or planning pregnancy
* Colonic adenomas over 1 cm, tumours or signs of active colitis on colonoscopy
* Status after colectomy or hemicolectomy
* Inflammatory bowel disease
* Immunocompromised individual
* Receiving biological/antibody treatment
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