Pistachio Snacking for Overweight and Obese Adults
Pistachio Snacking and Metabolic Flexibility
Recruiting
N/AInterventional Study
Overweight (BMI > 25)Obese But Otherwise Healthy ParticipantsOverweight or ObeseObese Patients (BMI ≥ 30 kg/m²)Poor Sleep QualityHealthy ParticipantsPhysically Inactive
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
25 – 45
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
60 (estimated)
Sponsor
University of South Carolina · Other
Who this trial is looking for
This trial is looking for overweight or obese adults aged 25 to 45 who have poor sleep quality. Participants will take part in two different eating plans: one where they snack on pistachios, and another with their regular food habits.
Are You a Good Fit for This Trial?
Rules you outType 1 diabetesType 2 diabetesPolycystic ovary syndromeCardiovascular diseasesNeuromuscular disordersMusculoskeletal disordersRecent cancer treatment
You may be able to join if
I am between 25 and 45 years old.
I am overweight or obese.
I have poor sleep quality.
I am healthy without serious medical conditions.
I do not meet the recommended physical activity levels.
I am not on a restrictive diet.
You may not be able to join if
I am allergic to nuts, especially tree nuts.
I have a pacemaker.
I have a health condition that may affect the study, like diabetes.
I have had gastrointestinal surgery.
I am pregnant or planning to become pregnant.
I am currently breastfeeding.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days o…
The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Males and Females
* Age: 25-45 years
* Overweight or obese (BMI=25.0-34.9 kg/m²)
* Poor sleep quality (Pittsburgh Sleep Quality Index ≥ 5)
* Healthy (no diagnosed metabolic, cardiovascular, sleep, or other health condition that may significantly alter metabolism, sleep, or abi…
Inclusion Criteria:
* Males and Females
* Age: 25-45 years
* Overweight or obese (BMI=25.0-34.9 kg/m²)
* Poor sleep quality (Pittsburgh Sleep Quality Index ≥ 5)
* Healthy (no diagnosed metabolic, cardiovascular, sleep, or other health condition that may significantly alter metabolism, sleep, or ability to participate in the exercise test)
* Not meeting weekly physical activity recommendations (\<150 min moderate-intensity exercise, \<75 minutes of vigorous-intensity exercise, and \<2 days of strength training)
* Not following a diet that is restrictive or eliminates certain food group/types
Exclusion Criteria:
* Allergies to nuts, especially tree nuts
* Has a pacemaker
* Following a diet that is restrictive or eliminates certain food group/types
* Self-repoted health or disease state that may influence study outcomes, including known metabolic or endocrine disorder (e.g. prediabetes, type 1 or type 2 diabetes, or polycystic ovary syndrome), cardiovascular diseases, neuromuscular disorders, musculoskeletal disorders; current or recent history of cancer/cancer treatment (within the past year)
* History of gastrointestinal surgery, hysterectomy
* For women: pregnant or thinking of becoming pregnant during the time of participation, pregnant within the last year, currently breastfeeding, or known to be perimenopausal
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