Biomarker-Driven Treatments for Metastatic Breast Cancer
Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies
Recruiting
Phase 2
Interventional Study
Breast Cancer
Metastatic Breast Cancer
Triple Negative Breast Cancer
Estrogen-receptor-positive Breast Cancer
Hormone Receptor Negative Breast Carcinoma
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 700 (estimated)
- Sponsor
- UNC Lineberger Comprehensive Cancer Center · Other
Who this trial is looking for
This trial is looking for patients with specific types of metastatic breast cancer to evaluate new treatment options. Participants will provide their medical data and receive standard therapies based on their tumor characteristics.
Are You a Good Fit for This Trial?
You may be able to join if
- I am at least 18 years old.
- I can provide written consent to participate.
- I am willing to follow study procedures.
- I have a performance status of 0-2.
You may not be able to join if
- I have a metastatic lesion that cannot be reached for a biopsy.
- I have already started a second-line therapy.
- I have a condition that my doctor thinks makes me inappropriate for the study.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
This is a multicenter, multi-arm, biomarker-stratified trial designed to evaluate biomarker-directed therapies in patients with estrogen receptor-positive/hormone receptor-negative (ER+/HR-) and triple-negative (TN) metastatic breast cancer (MBC). The trial integrates both retrospective and prospective data collection, including archival tumor tissue, medical record abstraction, and prospective tu…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Written informed consent obtained to participate in the study and HIPAA authorization for release of personal health information.
* Subject is willing and able to comply with study procedures based on the judgement of the investigator.
* Age ≥ 18 years of age at the time of co…
Contacts